Ontology highlight
ABSTRACT:
SUBMITTER: Martin-Rojas T
PROVIDER: S-EPMC4664895 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Martin-Rojas Tatiana T Mourino-Alvarez Laura L Alonso-Orgaz Sergio S Rosello-Lleti Esther E Calvo Enrique E Lopez-Almodovar Luis Fernando LF Rivera Miguel M Padial Luis R LR Lopez Juan Antonio JA de la Cuesta Fernando F Barderas Maria G MG
Scientific reports 20151201
Degenerative aortic stenosis (AS) is the most common worldwide cause of valve replacement. The aortic valve is a thin, complex, layered connective tissue with compartmentalized extracellular matrix (ECM) produced by specialized cell types, which directs blood flow in one direction through the heart. There is evidence suggesting remodeling of such ECM during aortic stenosis development. Thus, a better characterization of the role of ECM proteins in this disease would increase our understanding of ...[more]