Ontology highlight
ABSTRACT:
SUBMITTER: Yang XF
PROVIDER: S-EPMC4665683 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Yang Xiu-Fang XF Liu Guo-Sheng GS Li Min-Xu MX
Experimental and therapeutic medicine 20151014 6
The aim of this study was to investigate mutations of multidrug resistance 3 (MDR3) exons 9 and 23 in infants with parenteral nutrition-associated cholestasis (PNAC). A total of 41 infants with PNAC were enrolled in the study. Genomic DNA was extracted from the peripheral venous blood leukocytes of each patient and MDR3 exons 9 and 23 were amplified by polymerase chain reaction. One patient was identified who carried a frameshift mutation in MDR3 exon 23 (C.2793) that was caused by the insertion ...[more]