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Forty-five years of cell-cycle genetics.

ABSTRACT: In the early 1970s, studies in Leland Hartwell's laboratory at the University of Washington launched the genetic analysis of the eukaryotic cell cycle and set the path that has led to our modern understanding of this centrally important process. This 45th-anniversary Retrospective reviews the steps by which the project took shape, the atmosphere in which this happened, and the possible morals for modern times. It also provides an up-to-date look at the 35 original CDC genes and their human homologues.

SUBMITTER: Reid BJ 

PROVIDER: S-EPMC4666127 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Forty-five years of cell-cycle genetics.

Reid Brian J BJ   Culotti Joseph G JG   Nash Robert S RS   Pringle John R JR  

Molecular biology of the cell 20151201 24

In the early 1970s, studies in Leland Hartwell's laboratory at the University of Washington launched the genetic analysis of the eukaryotic cell cycle and set the path that has led to our modern understanding of this centrally important process. This 45th-anniversary Retrospective reviews the steps by which the project took shape, the atmosphere in which this happened, and the possible morals for modern times. It also provides an up-to-date look at the 35 original CDC genes and their human homol  ...[more]

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