Ontology highlight
ABSTRACT:
SUBMITTER: Dulin D
PROVIDER: S-EPMC4666362 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Dulin David D Vilfan Igor D ID Berghuis Bojk A BA Poranen Minna M MM Depken Martin M Dekker Nynke H NH
Nucleic acids research 20151022 21
Transcription in RNA viruses is highly dynamic, with a variety of pauses interrupting nucleotide addition by RNA-dependent RNA polymerase (RdRp). For example, rare but lengthy pauses (>20 s) have been linked to backtracking for viral single-subunit RdRps. However, while such backtracking has been well characterized for multi-subunit RNA polymerases (RNAPs) from bacteria and yeast, little is known about the details of viral RdRp backtracking and its biological roles. Using high-throughput magneti ...[more]