Ontology highlight
ABSTRACT:
SUBMITTER: Yamaguchi Y
PROVIDER: S-EPMC4666372 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Yamaguchi Yoshihiro Y Inouye Masayori M
Nucleic acids research 20151108 21
Almost all free-living bacteria contain toxin-antitoxin (TA) systems on their genomes and the targets of toxins are highly diverse. Here, we found a novel, previously unidentified TA system in Escherichia coli named yjhX-yjhQ. Induction of YjhX (85 amino acid residues) causes cell-growth arrest resulting in cell death, while YjhQ (181 residues) co-induction resumes cell growth. The primary cellular target of YjhX was found to be topoisomerase I (TopA), inhibiting both DNA replication and RNA syn ...[more]