Ontology highlight
ABSTRACT:
SUBMITTER: De Leonardis E
PROVIDER: S-EPMC4666395 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
De Leonardis Eleonora E Lutz Benjamin B Ratz Sebastian S Cocco Simona S Monasson Rémi R Schug Alexander A Weigt Martin M
Nucleic acids research 20150929 21
Despite the biological importance of non-coding RNA, their structural characterization remains challenging. Making use of the rapidly growing sequence databases, we analyze nucleotide coevolution across homologous sequences via Direct-Coupling Analysis to detect nucleotide-nucleotide contacts. For a representative set of riboswitches, we show that the results of Direct-Coupling Analysis in combination with a generalized Nussinov algorithm systematically improve the results of RNA secondary struc ...[more]