High Expression of Three-Gene Signature Improves Prediction of Relapse-Free Survival in Estrogen Receptor-Positive and Node-Positive Breast Tumors.
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ABSTRACT:
SUBMITTER: Thakkar A
PROVIDER: S-EPMC4666521 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
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High Expression of Three-Gene Signature Improves Prediction of Relapse-Free Survival in Estrogen Receptor-Positive and Node-Positive Breast Tumors.
Thakkar Arvind A Raj Hemanth H Ravishankar Muthuvelan Bhaskaran B Balakrishnan Arun A Padigaru Muralidhara M
Biomarker insights 20151130
The objective of the present study was to validate prognostic gene signature for estrogen receptor alpha-positive (ER03B1+) and lymph node (+) breast cancer for improved selection of patients for adjuvant therapy. In our previous study, we identified a group of seven genes (GATA3, NTN4, SLC7A8, ENPP1, MLPH, LAMB2, and PLAT) that show elevated messenger RNA (mRNA) expression levels in ERα (+) breast cancer patient samples. The prognostic values of these genes were evaluated using gene expression ...[more]
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