Ontology highlight
ABSTRACT:
SUBMITTER: Jin SG
PROVIDER: S-EPMC4666751 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Jin Seung-Gi SG Xiong Wenying W Wu Xiwei X Yang Lu L Pfeifer Gerd P GP
Genomics 20150915 6
Using MIRA-seq, we have characterized the DNA methylome of metastatic melanoma and normal melanocytes. Individual tumors contained several thousand hypermethylated regions. We discovered 179 tumor-specific methylation peaks present in all (27/27) melanomas that may be effective disease biomarkers, and 3113 methylation peaks were seen in >40% of the tumors. We found that 150 of the approximately 1200 tumor-associated methylation peaks near transcription start sites (TSSs) were marked by H3K27me3 ...[more]