Ontology highlight
ABSTRACT:
SUBMITTER: Hammer C
PROVIDER: S-EPMC4667104 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Hammer Christian C Begemann Martin M McLaren Paul J PJ Bartha István I Michel Angelika A Klose Beate B Schmitt Corinna C Waterboer Tim T Pawlita Michael M Schulz Thomas F TF Ehrenreich Hannelore H Fellay Jacques J
American journal of human genetics 20151008 5
The magnitude of the human antibody response to viral antigens is highly variable. To explore the human genetic contribution to this variability, we performed genome-wide association studies of the immunoglobulin G response to 14 pathogenic viruses in 2,363 immunocompetent adults. Significant associations were observed in the major histocompatibility complex region on chromosome 6 for influenza A virus, Epstein-Barr virus, JC polyomavirus, and Merkel cell polyomavirus. Using local imputation and ...[more]