Preventive effects of vitamin D treatment on bleomycin-induced pulmonary fibrosis.
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ABSTRACT:
SUBMITTER: Zhang Z
PROVIDER: S-EPMC4667265 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Publications
Preventive effects of vitamin D treatment on bleomycin-induced pulmonary fibrosis.
Zhang Zongmei Z Yu Xiaoting X Fang Xia X Liang Aibin A Yu Zhang Z Gu Pan P Zeng Yu Y He Jian J Zhu Hailong H Li Shuai S Fan Desheng D Han Fei F Zhang Lanjing L Yi Xianghua X
Scientific reports 20151202
Patients with pulmonary fibrosis often have low vitamin D levels, the effects of which are largely unknown. We here report that early vitamin D supplementation significantly reduced the severity of pulmonary fibrosis and inflammatory cell accumulationin in the bleomycin-induced pulmonary fibrosis mouse model on supplementary days 14, 21 and 28 (P < 0.001). Vitamin D supplementation also prevented some ultrastructural changes in response to bleomycin administration, including basement membrane th ...[more]
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