Ontology highlight
ABSTRACT:
SUBMITTER: Chun L
PROVIDER: S-EPMC4667614 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Nature communications 20151105
The nervous system plays an important but poorly understood role in modulating longevity. GABA, a prominent inhibitory neurotransmitter, is best known to regulate nervous system function and behaviour in diverse organisms. Whether GABA signalling affects aging, however, has not been explored. Here we examined mutants lacking each of the major neurotransmitters in C. elegans, and find that deficiency in GABA signalling extends lifespan. This pro-longevity effect is mediated by the metabotropic GA ...[more]