Ontology highlight
ABSTRACT:
SUBMITTER: Matsumoto Y
PROVIDER: S-EPMC4667635 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Matsumoto Yuri Y Chen Ritchie R Anikeeva Polina P Jasanoff Alan A
Nature communications 20151102
Remote measurement and manipulation of biological systems can be achieved using magnetic techniques, but a missing link is the availability of highly magnetic handles on cellular or molecular function. Here we address this need by using high-throughput genetic screening in yeast to select variants of the iron storage ferritin (Ft) that display enhanced iron accumulation under physiological conditions. Expression of Ft mutants selected from a library of 10(7) variants induces threefold greater ce ...[more]