Ontology highlight
ABSTRACT:
SUBMITTER: Irie M
PROVIDER: S-EPMC4667679 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
The Journal of veterinary medical science 20150612 11
A 13-year-old spayed mixed-breed dog was diagnosed with a gastrointestinal stromal tumor (GIST) after histopathological examination of an abdominal mass. Five months after surgical resection of the tumor, we detected the recurrence of GIST with multiple disseminated abdominal lesions. A sequence analysis of cDNA obtained from a biopsy of the recurrent tumors revealed a mutation within exon 9 of the c-kit gene (1523A>T, Asn(508)Ile), which has been shown to cause ligand-independent phosphorylatio ...[more]