Relationship between three novel SNPs of BRCA1 and canine mammary tumors.
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ABSTRACT:
SUBMITTER: Sun W
PROVIDER: S-EPMC4667680 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Publications
Relationship between three novel SNPs of BRCA1 and canine mammary tumors.
Sun Weidong W Yang Xu X Qiu Hengbin H Zhang Di D Wang Huanan H Huang Jian J Lin Degui D
The Journal of veterinary medical science 20150705 11
The BRCA1 gene plays an important role in the development of human breast cancer, and recent research indicated that genetic variations of BRCA1 are also related to canine mammary tumors (CMTs). Here, using rapid amplification of cDNA ends (RACE), we cloned the 5'- and 3'-UTRs of BRCA1. By direct sequencing of the flanking sequences of the 5'- and 3'-UTRs of BRCA1, three previously unreported single-nucleotide polymorphisms (SNPs) were identified, two (-1228T >C, -1173C >T) in the putative promo ...[more]
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