Ontology highlight
ABSTRACT:
SUBMITTER: Cantoni C
PROVIDER: S-EPMC4667728 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Cantoni Claudia C Bollman Bryan B Licastro Danilo D Xie Mingqiang M Mikesell Robert R Schmidt Robert R Yuede Carla M CM Galimberti Daniela D Olivecrona Gunilla G Klein Robyn S RS Cross Anne H AH Otero Karel K Piccio Laura L
Acta neuropathologica 20150129 3
Microglia are phagocytic cells that survey the brain and perform neuroprotective functions in response to tissue damage, but their activating receptors are largely unknown. Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial immunoreceptor whose loss-of-function mutations in humans cause presenile dementia, while genetic variants are associated with increased risk of neurodegenerative diseases. In myeloid cells, TREM2 has been involved in the regulation of phagocytosis, cell ...[more]