Critical behavior of subcellular density organization during neutrophil activation and migration.

ABSTRACT: Physical theories of active matter continue to provide a quantitative understanding of dynamic cellular phenomena, including cell locomotion. Although various investigations of the rheology of cells have identified important viscoelastic and traction force parameters for use in these theoretical approaches, a key variable has remained elusive both in theoretical and experimental approaches: the spatiotemporal behavior of the subcellular density. The evolution of the subcellular density has been qualitatively observed for decades as it provides the source of image contrast in label-free imaging modalities (e.g., differential interference contrast, phase contrast) used to investigate cellular specimens. While these modalities directly visualize cell structure, they do not provide quantitativ

SUBMITTER: Baker-Groberg SM 

PROVIDER: S-EPMC4667984 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature