Ontology highlight
ABSTRACT:
SUBMITTER: Vieira NM
PROVIDER: S-EPMC4668935 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Cell 20151112 5
Duchenne muscular dystrophy (DMD), caused by mutations at the dystrophin gene, is the most common form of muscular dystrophy. There is no cure for DMD and current therapeutic approaches to restore dystrophin expression are only partially effective. The absence of dystrophin in muscle results in dysregulation of signaling pathways, which could be targets for disease therapy and drug discovery. Previously, we identified two exceptional Golden Retriever muscular dystrophy (GRMD) dogs that are mildl ...[more]