Ontology highlight
ABSTRACT:
SUBMITTER: Xu X
PROVIDER: S-EPMC4669061 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Xu Xiaozhou X Zhi Xiaoduo X Leng Fenfei F
Biochimie 20120823 12
DNA supercoiling plays a critical role in certain essential DNA transactions, such as DNA replication, recombination, and transcription. For this reason, exploring energetics of DNA supercoiling is fundamentally important for understanding its biological functions. In this paper, using a unique property of DNA intercalators, such as ethidium bromide and daunorubicin, which bind to supercoiled, nicked, and relaxed DNA templates with different DNA-binding enthalpies, we determined DNA supercoiling ...[more]