Ontology highlight
ABSTRACT:
SUBMITTER: Xu C
PROVIDER: S-EPMC4669521 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Xu Cheng C Qu Hongzhu H Wang Guangyu G Xie Bingbing B Shi Yi Y Yang Yaran Y Zhao Zhao Z Hu Lan L Fang Xiangdong X Yan Jiangwei J Feng Lei L
Scientific reports 20151204
High deviations resulting from prediction model, gender and population difference have limited age estimation application of DNA methylation markers. Here we identified 2,957 novel age-associated DNA methylation sites (P < 0.01 and R(2) > 0.5) in blood of eight pairs of Chinese Han female monozygotic twins. Among them, nine novel sites (false discovery rate < 0.01), along with three other reported sites, were further validated in 49 unrelated female volunteers with ages of 20-80 years by Sequeno ...[more]