Ontology highlight
ABSTRACT:
SUBMITTER: Subramanian G
PROVIDER: S-EPMC4669537 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Subramanian Govindan G Sud Manish M
ACS medicinal chemistry letters 20100728 8
An exhaustive computational exercise on a comprehensive set of 15 therapeutic kinase inhibitors was undertaken to identify as to which compounds hit which kinase off-targets in the human kinome. Although the kinase selectivity propensity of each inhibitor against ∼480 kinase targets is predicted, we compared our predictions to ∼280 kinase targets for which consistent experimental data are available and demonstrate an overall average prediction accuracy and specificity of ∼90%. A comparison of th ...[more]