Ontology highlight
ABSTRACT:
SUBMITTER: Yu X
PROVIDER: S-EPMC4669973 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Yu Xiang X Sargaeva Nadezda P NP Thompson Christopher J CJ Costello Catherine E CE Lin Cheng C
International journal of mass spectrometry 20151101
Deamidation and the subsequent formation of isoaspartic acid (isoAsp) are common modifications of asparagine (Asn) residues in proteins. Differentiation of isoAsp and Asp residues is a challenging task owing to their similar chemical properties and identical molecular mass. Recent studies showed that they can be differentiated using electron capture dissociation (ECD) which generates diagnostic fragments <i>c</i>'+57 and <i>z</i><sup>•</sup>-57 specific to the isoAsp residue. However, the ECD ap ...[more]