Synapse Loss and Dendrite Remodeling in a Mouse Model of Glaucoma.
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ABSTRACT:
SUBMITTER: Berry RH
PROVIDER: S-EPMC4670161 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Synapse Loss and Dendrite Remodeling in a Mouse Model of Glaucoma.
Berry Ryan H RH Qu Juan J John Simon W M SW Howell Gareth R GR Jakobs Tatjana C TC
PloS one 20151204 12
It has been hypothesized that synaptic pruning precedes retinal ganglion cell degeneration in glaucoma, causing early dysfunction to retinal ganglion cells. To begin to assess this, we studied the excitatory synaptic inputs to individual ganglion cells in normal mouse retinas and in retinas with ganglion cell degeneration from glaucoma (DBA/2J), or following an optic nerve crush. Excitatory synapses were labeled by AAV2-mediated transfection of ganglion cells with PSD-95-GFP. After both insults ...[more]
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