Ontology highlight
ABSTRACT:
SUBMITTER: Khare D
PROVIDER: S-EPMC4670573 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Khare Dheeraj D Hale Wendi A WA Tripathi Ashootosh A Gu Liangcai L Sherman David H DH Gerwick William H WH Håkansson Kristina K Smith Janet L JL
Structure (London, England : 1993) 20151029 12
The natural product curacin A, a potent anticancer agent, contains a rare cyclopropane group. The five enzymes for cyclopropane biosynthesis are highly similar to enzymes that generate a vinyl chloride moiety in the jamaicamide natural product. The structural biology of this remarkable catalytic adaptability is probed with high-resolution crystal structures of the curacin cyclopropanase (CurF ER), an in vitro enoyl reductase (JamJ ER), and a canonical curacin enoyl reductase (CurK ER). The JamJ ...[more]