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Pregnancy-associated cardiomyopathy in survivors of childhood cancer.


ABSTRACT: Current information regarding pregnancy-associated cardiomyopathy among women treated for childhood cancer is insufficient to appropriately guide counseling and patient management. This study aims to characterize its prevalence within a large cohort of females exposed to cardiotoxic therapy.This is a retrospective cohort study of female cancer survivors treated at St. Jude Children's Research Hospital between 1963 and 2006, at least 5 years from diagnosis, ?13 years old at last follow-up, and with at least one successful pregnancy. Pregnancy-associated cardiomyopathy was defined as shortening fraction <28 % or ejection fraction <50 % or treatment for cardiomyopathy during or up to 5 months after completion of pregnancy.Among the 847 female cancer survivors with 1554 completed pregnancies, only 3 (0.3 %) developed pregnancy-associated cardiomyopathy and 40 developed non-pregnancy-associated cardiomyopathy either 5 months postpartum (n?=?14) or prior to pregnancy (n?=?26). Among those with cardiomyopathy prior to pregnancy (n?=?26), cardiac function deteriorated during pregnancy in eight patients (three patients with normalization of cardiac function prior to pregnancy, three with persistently abnormal cardiac function, and two for whom resolution of cardiomyopathy was unknown prior to pregnancy). Patients that developed cardiomyopathy received a higher median dose of anthracyclines compared to those that did not (321 versus 164 mg/m(2); p?

SUBMITTER: Hines MR 

PROVIDER: S-EPMC4670599 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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Pregnancy-associated cardiomyopathy in survivors of childhood cancer.

Hines Melissa R MR   Mulrooney Daniel A DA   Hudson Melissa M MM   Ness Kirsten K KK   Green Daniel M DM   Howard Scott C SC   Krasin Matthew M   Metzger Monika L ML  

Journal of cancer survivorship : research and practice 20150605 1


<h4>Purpose</h4>Current information regarding pregnancy-associated cardiomyopathy among women treated for childhood cancer is insufficient to appropriately guide counseling and patient management. This study aims to characterize its prevalence within a large cohort of females exposed to cardiotoxic therapy.<h4>Methods</h4>This is a retrospective cohort study of female cancer survivors treated at St. Jude Children's Research Hospital between 1963 and 2006, at least 5 years from diagnosis, ≥13 yea  ...[more]

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