Association between use of warfarin with common sulfonylureas and serious hypoglycemic events: retrospective cohort analysis.

ABSTRACT:

Study question

Is warfarin use associated with an increased risk of serious hypoglycemic events among older people treated with the sulfonylureas glipizide and glimepiride?

Methods

This was a retrospective cohort analysis of pharmacy and medical claims from a 20% random sample of Medicare fee for service beneficiaries aged 65 years or older. It included 465,918 beneficiaries with diabetes who filled a prescription for glipizide or glimepiride between 2006 and 2011 (4,355,418 person quarters); 71,895 (15.4%) patients also filled a prescription for warfarin (416,479 person quarters with warfarin use). The main outcome measure was emergency department visit or hospital admission with a primary diagnosis of hypoglycemia in person quarters with concurrent fills of warfarin and gl

SUBMITTER: Romley JA 

PROVIDER: S-EPMC4670968 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature