Ontology highlight
ABSTRACT:
SUBMITTER: Chen JC
PROVIDER: S-EPMC4670983 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Cell systems 20151101 5
Network-based molecular modeling of physiological behaviors has proven invaluable in the study of complex diseases such as cancer, but these approaches remain largely untested in contexts involving interacting tissues such as autoimmunity. Here, using Alopecia Areata (AA) as a model, we have adapted regulatory network analysis to specifically isolate physiological behaviors in the skin that contribute to the recruitment of immune cells in autoimmune disease. We use context-specific regulatory ne ...[more]