Helicobacter pylori-induced inflammation and epigenetic changes during gastric carcinogenesis.

ABSTRACT: The sequence of events associated with the development of gastric cancer has been described as "the gastric precancerous cascade". This cascade is a dynamic process that includes lesions, such as atrophic gastritis, intestinal metaplasia and dysplasia. According to this model, Helicobacter pylori (H. pylori) infection targets the normal gastric mucosa causing non-atrophic gastritis, an initiating lesion that can be cured by clearing H. pylori with antibiotics or that may then linger in the case of chronic infection and progress to atrophic gastritis. The presence of virulence factors in the infecting H. pylori drives the carcinogenesis process. Independent epidemiological and animal studies have confirmed the sequential progression of these precancerous lesions. Particularly long-term foll

SUBMITTER: Valenzuela MA 

PROVIDER: S-EPMC4671030 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature