Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC4671119 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Li Yanping Y Zhou Yangyang Y Jiang Jiayu J Wang Xinyi X Fu Yao Y Gong Tao T Sun Xun X Zhang Zhirong Z
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20150708 12
The first molecular insights into how prodrugs modified with ethanolamine-related structures target the brain were generated using an in vitro BBB model and in situ perfusion technique. Prodrugs were delivered safely and efficiently to the brain through tight interaction with the anionic membrane of brain capillary endothelial cells, observed as a shift in zeta potential, followed by uptake into the cells. Prodrugs III and IV carrying primary and secondary amine modifications appeared to enter t ...[more]