Ontology highlight
ABSTRACT:
SUBMITTER: Buckley EM
PROVIDER: S-EPMC4671120 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Buckley Erin M EM Miller Benjamin F BF Golinski Julianne M JM Sadeghian Homa H McAllister Lauren M LM Vangel Mark M Ayata Cenk C Meehan William P WP Franceschini Maria Angela MA Whalen Michael J MJ
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20150708 12
Repetitive concussions are associated with long-term cognitive dysfunction that can be attenuated by increasing the time intervals between concussions; however, biomarkers of the safest rest interval between injuries remain undefined. We hypothesize that deranged cerebral blood flow (CBF) is a candidate biomarker for vulnerability to repetitive concussions. Using a mouse model of human concussion, we examined the effect of single and repetitive concussions on cognition and on an index of CBF (CB ...[more]