Dataset Information

Alzheimer's Genetic Risk Intensifies Neurocognitive Slowing Associated with Diabetes in Non-Demented Older Adults.

ABSTRACT:

Introduction

We examine interactive and intensification effects of type 2 diabetes (T2D) with APOE and an Alzheimer's disease Genetic Risk Score (GRS) on neurocognitive speed performance and change in non-demented older adults.

Methods

In an accelerated longitudinal design, we used latent growth modeling to test moderators of level and change in a neurocognitive speed latent variable for 628 adults (baseline M age=69.0) followed over 9 years. The GRS was compiled using the cumulative risk of APOE, CLU, CR1, and PICALM.

Results

First, T2D predicted slower speed performance at centering age (75). Second, no predictive effects were associated with APOE or GRS. Third, a significant interaction showed that high risk from both T2D and GRS was selectively associated with steeper longitudinal slowing than all comparison cross-domain risk groups.

Discussion

Higher AD-related genetic risk intensified deleterious effects of diabetes on neurocognitive slowing in non-demented aging beyond the independent influence of APOE.

SUBMITTER: McFall GP

PROVIDER: S-EPMC4671298 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Publications

Alzheimer's Genetic Risk Intensifies Neurocognitive Slowing Associated with Diabetes in Non-Demented Older Adults.

McFall G Peggy GP Wiebe Sandra A SA Vergote David D Anstey Kaarin J KJ Dixon Roger A RA

Alzheimer's & dementia (Amsterdam, Netherlands) 20151201 4

<h4>Introduction</h4>We examine interactive and intensification effects of type 2 diabetes (T2D) with <i>APOE</i> and an Alzheimer's disease Genetic Risk Score (GRS) on neurocognitive speed performance and change in non-demented older adults.<h4>Methods</h4>In an accelerated longitudinal design, we used latent growth modeling to test moderators of level and change in a neurocognitive speed latent variable for 628 adults (baseline <i>M</i> age=69.0) followed over 9 years. The GRS was compiled usi ...[more]

PMID: 26665159

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Project description:IntroductionGiven rapid global population aging, developing interventions against age-associated cognitive decline is an important medical and societal goal. We evaluated a cognitive training protocol combined with transcranial direct current stimulation (tDCS) on trained and non-trained functions in non-demented older adults.MethodsFifty-six older adults (65-80 years) were randomly assigned to one of two interventional groups, using age and baseline performance as strata. Both groups performed a nine-session cognitive training over 3 weeks with either concurrent anodal tDCS (atDCS, 1 mA, 20 minutes) over the left dorsolateral prefrontal cortex (target intervention) or sham stimulation (control intervention). Primary outcome was performance on the trained letter updating task immediately after training. Secondary outcomes included performance on other executive and memory (near and far transfer) tasks. All tasks were administered at baseline, post-intervention, and at 1- and 7-month follow-up assessments. Prespecified analyses to investigate treatment effects were conducted using mixed-model analyses.ResultsNo between-group differences emerged in the trained letter updating and Markov decision-making tasks at post-intervention and at follow-up timepoints. Secondary analyses revealed group differences in one near-transfer task: Superior n-back task performance was observed in the tDCS group at post-intervention and at follow-up. No such effects were observed for the other transfer tasks. Improvements in working memory were associated with individually induced electric field strengths.DiscussionCognitive training with atDCS did not lead to superior improvement in trained task performance compared to cognitive training with sham stimulation. Thus, our results do not support the immediate benefit of tDCS-assisted multi-session cognitive training on the trained function. As the intervention enhanced performance in a near-transfer working memory task, we provide exploratory evidence for effects on non-trained working memory functions in non-demented older adults that persist over a period of 1 month.

Dataset Information

Alzheimer's Genetic Risk Intensifies Neurocognitive Slowing Associated with Diabetes in Non-Demented Older Adults.

Introduction

Methods

Results

Discussion

Publications

Alzheimer's Genetic Risk Intensifies Neurocognitive Slowing Associated with Diabetes in Non-Demented Older Adults.

Similar Datasets

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