Ontology highlight
ABSTRACT:
SUBMITTER: Ramanan VK
PROVIDER: S-EPMC4671479 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Brain : a journal of neurology 20150811 Pt 10
Brain amyloid deposition is thought to be a seminal event in Alzheimer's disease. To identify genes influencing Alzheimer's disease pathogenesis, we performed a genome-wide association study of longitudinal change in brain amyloid burden measured by (18)F-florbetapir PET. A novel association with higher rates of amyloid accumulation independent from APOE (apolipoprotein E) ε4 status was identified in IL1RAP (interleukin-1 receptor accessory protein; rs12053868-G; P = 1.38 × 10(-9)) and was valid ...[more]