Ontology highlight
ABSTRACT:
SUBMITTER: Moukambi F
PROVIDER: S-EPMC4671657 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Moukambi Félicien F Rabezanahary Henintsoa H Rodrigues Vasco V Racine Gina G Robitaille Lynda L Krust Bernard B Andreani Guadalupe G Soundaramourty Calayselvy C Silvestre Ricardo R Laforge Mireille M Estaquier Jérôme J
PLoS pathogens 20151207 12
Follicular T helper cells (Tfh), a subset of CD4 T lymphocytes, provide crucial help to B cells in the production of antigen-specific antibodies. Although several studies have analyzed the dynamics of Tfh cells in peripheral blood and lymph nodes (LNs) during Aids, none has yet addressed the impact of SIV infection on the dynamics of Tfh cells in the spleen, the primary organ of B cell activation. We show here a significant decrease in splenic Tfh cells in SIVmac251-infected rhesus macaques (RMs ...[more]