Ontology highlight
ABSTRACT:
SUBMITTER: Montesinos MS
PROVIDER: S-EPMC4672385 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Montesinos Mónica S MS Dong Wei W Goff Kevin K Das Brati B Guerrero-Given Debbie D Schmalzigaug Robert R Premont Richard T RT Satterfield Rachel R Kamasawa Naomi N Young Samuel M SM
Neuron 20151201 5
A cytomatrix of proteins at the presynaptic active zone (CAZ) controls the strength and speed of neurotransmitter release at synapses in response to action potentials. However, the functional role of many CAZ proteins and their respective isoforms remains unresolved. Here, we demonstrate that presynaptic deletion of the two G protein-coupled receptor kinase-interacting proteins (GITs), GIT1 and GIT2, at the mouse calyx of Held leads to a large increase in AP-evoked release with no change in the ...[more]