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Kinetics of Serologic Responses to MERS Coronavirus Infection in Humans, South Korea.

ABSTRACT: We investigated the kinetics of serologic responses to Middle East respiratory syndrome coronavirus (MERS-CoV) infection by using virus neutralization and MERS-CoV S1 IgG ELISA tests. In most patients, robust antibody responses developed by the third week of illness. Delayed antibody responses with the neutralization test were associated with more severe disease.

SUBMITTER: Park WB

PROVIDER: S-EPMC4672454 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Kinetics of Serologic Responses to MERS Coronavirus Infection in Humans, South Korea.

Park Wan Beom WB Perera Ranawaka A P M RA Choe Pyoeng Gyun PG Lau Eric H Y EH Choi Seong Jin SJ Chun June Young JY Oh Hong Sang HS Song Kyoung-Ho KH Bang Ji Hwan JH Kim Eu Suk ES Kim Hong Bin HB Park Sang Won SW Kim Nam Joong NJ Man Poon Leo Lit LL Peiris Malik M Oh Myoung-Don MD

Emerging infectious diseases 20151201 12

We investigated the kinetics of serologic responses to Middle East respiratory syndrome coronavirus (MERS-CoV) infection by using virus neutralization and MERS-CoV S1 IgG ELISA tests. In most patients, robust antibody responses developed by the third week of illness. Delayed antibody responses with the neutralization test were associated with more severe disease. ...[more]

PMID: 26583829

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Project description:Background. Since the emergence of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in 2012, more than 1,300 laboratory confirmed cases of MERS-CoV infections have been reported in Asia, North Africa, and Europe by July 2015. The recent MERS-CoV nosocomial outbreak in South Korea quickly became the second largest such outbreak with 186 total cases and 36 deaths in a little more than one month, second only to Saudi Arabia in country-specific number of reported cases. Methods. We use a simple mathematical model, the Richards model, to trace the temporal course of the South Korea MERS-CoV outbreak. We pinpoint its outbreak turning point and its transmissibility via basic reproduction number R 0 in order to ascertain the occurrence of this nosocomial outbreak and how it was quickly brought under control. Results. The estimated outbreak turning point of ti = 23.3 days (95% CI [22.6-24.0]), or 23-24 days after the onset date of the index case on May 11, pinpoints June 3-4 as the time of the turning point or the peak incidence for this outbreak by onset date. R 0 is estimated to range between 7.0 and 19.3. Discussion and Conclusion. The turning point of the South Korea MERS-CoV outbreak occurred around May 27-29, when control measures were quickly implemented after laboratory confirmation of the first cluster of nosocomial infections by the index patient. Furthermore, transmissibility of MERS-CoV in the South Korea outbreak was significantly higher than those reported from past MERS-CoV outbreaks in the Middle East, which is attributable to the nosocomial nature of this outbreak. Our estimate of R 0 for the South Korea MERS-CoV nosocomial outbreak further highlights the importance and the risk involved in cluster infections and superspreading events in crowded settings such as hospitals. Similar to the 2003 SARS epidemic, outbreaks of infectious diseases with low community transmissibility like MERS-CoV could still occur initially with large clusters of nosocomial infections, but can be quickly and effectively controlled with timely intervention measures.

Dataset Information

Kinetics of Serologic Responses to MERS Coronavirus Infection in Humans, South Korea.

Publications

Kinetics of Serologic Responses to MERS Coronavirus Infection in Humans, South Korea.

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