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BCG Induced Necrosis of the Entire Bladder Urothelium.

ABSTRACT: Instillation therapy with attenuated tuberculosis bacteria (BCG) can significantly reduce rates of recurrence of non-muscle invasive bladder cancer. Local and systemic side effects such as dysuria, irritative voiding symptoms or partial bladder contracture and systemic inflammation were reported. A 75 year-old male patient with recurrent non muscle invasive bladder cancer developed necrosis of the entire bladder urothelium more than six years after BCG instillation immunotherapy. The resulting irritative voiding symptoms and low bladder capacity required radical cystectomy. BCG instillation can cause severe side effects, which develop gradually and eventually need radical surgical therapy such as cystectomy without tumor recurrence.

SUBMITTER: Kronig M

PROVIDER: S-EPMC4672657 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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BCG Induced Necrosis of the Entire Bladder Urothelium.

Krönig Malte M Jilg Cordula C Burger Dieter D Langer Mathias M Timme-Bronsert Sylvia S Werner Martin M Wetterauer Ulrich U Seemann Wolfgang-Schultze WS

Urology case reports 20150621 5

Instillation therapy with attenuated tuberculosis bacteria (BCG) can significantly reduce rates of recurrence of non-muscle invasive bladder cancer. Local and systemic side effects such as dysuria, irritative voiding symptoms or partial bladder contracture and systemic inflammation were reported. A 75 year-old male patient with recurrent non muscle invasive bladder cancer developed necrosis of the entire bladder urothelium more than six years after BCG instillation immunotherapy. The resulting i ...[more]

PMID: 26793538

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