Ontology highlight
ABSTRACT:
SUBMITTER: Muretta JM
PROVIDER: S-EPMC4672802 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Muretta Joseph M JM Jun Yonggun Y Gross Steven P SP Major Jennifer J Thomas David D DD Rosenfeld Steven S SS
Proceedings of the National Academy of Sciences of the United States of America 20151116 48
Kinesins perform mechanical work to power a variety of cellular functions, from mitosis to organelle transport. Distinct functions shape distinct enzymologies, and this is illustrated by comparing kinesin-1, a highly processive transport motor that can work alone, to Eg5, a minimally processive mitotic motor that works in large ensembles. Although crystallographic models for both motors reveal similar structures for the domains involved in mechanochemical transduction--including switch-1 and the ...[more]