Resting-state functional connectivity predicts longitudinal change in autistic traits and adaptive functioning in autism.

ABSTRACT: Although typically identified in early childhood, the social communication symptoms and adaptive behavior deficits that are characteristic of autism spectrum disorder (ASD) persist throughout the lifespan. Despite this persistence, even individuals without cooccurring intellectual disability show substantial heterogeneity in outcomes. Previous studies have found various behavioral assessments [such as intelligence quotient (IQ), early language ability, and baseline autistic traits and adaptive behavior scores] to be predictive of outcome, but most of the variance in functioning remains unexplained by such factors. In this study, we investigated to what extent functional brain connectivity measures obtained from resting-state functional connectivity MRI (rs-fcMRI) could predict the variance

SUBMITTER: Plitt M 

PROVIDER: S-EPMC4672806 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature