Ontology highlight
ABSTRACT:
SUBMITTER: Polo ML
PROVIDER: S-EPMC4673148 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Polo María Laura ML Riggio Marina M May María M Rodríguez María Jimena MJ Perrone María Cecilia MC Stallings-Mann Melody M Kaen Diego D Frost Marlene M Goetz Matthew M Boughey Judy J Lanari Claudia C Radisky Derek D Novaro Virginia V
Oncotarget 20150901 26
Improved efficacy of neoadjuvant endocrine-targeting therapies in luminal breast carcinomas could be achieved with optimal use of pathway targeting agents. In a mouse model of ductal breast carcinoma we identify a tumor regressive stromal reaction that is induced by neoadjuvant endocrine therapy. This reparative reaction is characterized by tumor neovascularization accompanied by infiltration of immune cells and carcinoma-associated fibroblasts that stain for phosphorylated ribosomal protein S6 ...[more]