Ontology highlight
ABSTRACT:
SUBMITTER: Lim B
PROVIDER: S-EPMC4673155 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Lim Byungho B Mun Jihyeob J Kim Jeong-Hwan JH Kim Chan Wook CW Roh Seon Ae SA Cho Dong-Hyung DH Kim Yong Sung YS Kim Seon-Young SY Kim Jin Cheon JC
Oncotarget 20150901 26
To characterize the mutation profiles of colorectal cancer (CRC) primary tumors (PTs) and liver metastases (CLMs), we performed both whole-exome and RNA sequencing. Ten significantly mutated genes, including BMI1, CARD11, and NRG1, were found in 34 CRCs with CLMs. We defined three mutation classes (Class 1 to 3) based on the absence or presence of mutations during liver metastasis. Most mutations were classified into Class 1 (shared between PTs and CLMs), suggesting the common clonal origin of P ...[more]