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ABSTRACT: Background
The Child-Turcotte-Pugh score (CTP) is the standard tool for hepatic reserve assessment in hepatocellular carcinoma (HCC). Recently, we reported that integrating plasma insulin-like growth factor-1 (IGF-1) level into the CTP score was associated with better patient risk stratification in two U.S. independent cohorts. Our current study aimed to validate the IGF-CTP score in patients who have different demographics and risk factors.Patients and methods
We prospectively recruited 100 Egyptian patients and calculated their IGF-CTP score compared to CTP score. C-index was used to compare the prognostic significance of the two scoring systems. Finally, we compared our results with our U.S. cohorts published data.Results
IGF-CTP score showed significant better patient stratification compared to CTP score in the international validation cohort. Among CTP class A patients, who usually considered for active treatment and clinical trial enrollment, 32.5% were reclassified as IGF-CTP class B with significantly shorter OS than patients reclassified as class A with hazard ratio [HR] = 6.15, 95% confidence interval [CI] = 2.18 -17.37.Conclusions
IGF-CTP score showed significantly better patient stratification and survival prediction not only in the U.S. population but also in international validation population, who had different demographics and HCC risk factors.
SUBMITTER: Abdel-Wahab R
PROVIDER: S-EPMC4673259 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Abdel-Wahab Reham R Shehata Samir S Hassan Manal M MM Xiao Lianchun L Lee Ju-Seog JS Cheung Sheree S Essa Hoda H HH Hassabo Hesham M HM Shalaby Ahmed S AS Mosad Eman E Raghav Kanwal K Rashid Asif A Wolff Robert A RA Morris Jeffrey S JS Amin Hesham M HM Kaseb Ahmed O AO
Oncotarget 20150801 25
<h4>Background</h4>The Child-Turcotte-Pugh score (CTP) is the standard tool for hepatic reserve assessment in hepatocellular carcinoma (HCC). Recently, we reported that integrating plasma insulin-like growth factor-1 (IGF-1) level into the CTP score was associated with better patient risk stratification in two U.S. independent cohorts. Our current study aimed to validate the IGF-CTP score in patients who have different demographics and risk factors.<h4>Patients and methods</h4>We prospectively r ...[more]