Ontology highlight
ABSTRACT:
SUBMITTER: Heinemann A
PROVIDER: S-EPMC4673282 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Heinemann Anja A Cullinane Carleen C De Paoli-Iseppi Ricardo R Wilmott James S JS Gunatilake Dilini D Madore Jason J Strbenac Dario D Yang Jean Y JY Gowrishankar Kavitha K Tiffen Jessamy C JC Prinjha Rab K RK Smithers Nicholas N McArthur Grant A GA Hersey Peter P Gallagher Stuart J SJ
Oncotarget 20150801 25
Histone acetylation marks have an important role in controlling gene expression and are removed by histone deacetylases (HDACs). These marks are read by bromodomain and extra-terminal (BET) proteins and novel inhibitiors of these proteins are currently in clinical development. Inhibitors of HDAC and BET proteins have individually been shown to cause apoptosis and reduce growth of melanoma cells. Here we show that combining the HDAC inhibitor LBH589 and BET inhibitor I-BET151 synergistically indu ...[more]