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Synthesis and Biological Evaluation of New Hydrazone Derivatives of Quinoline and Their Cu(II) and Zn(II) Complexes against Mycobacterium tuberculosis.

ABSTRACT: A new series of quinoline hydrazone derivatives and their metal complexes have been synthesized and their biological properties have been evaluated against Mycobacterium tuberculosis (H37 RV strain). Most of the newly synthesized compounds displayed 100% inhibitory activity at a concentration of 6.25-25??g/mL, against Mycobacterium tuberculosis. Fluorescence properties of all the synthesized compounds have been studied.

SUBMITTER: Mandewale MC 

PROVIDER: S-EPMC4673354 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Synthesis and Biological Evaluation of New Hydrazone Derivatives of Quinoline and Their Cu(II) and Zn(II) Complexes against Mycobacterium tuberculosis.

Mandewale Mustapha C MC   Thorat Bapu B   Shelke Dnyaneshwar D   Yamgar Ramesh R  

Bioinorganic chemistry and applications 20151125

A new series of quinoline hydrazone derivatives and their metal complexes have been synthesized and their biological properties have been evaluated against Mycobacterium tuberculosis (H37 RV strain). Most of the newly synthesized compounds displayed 100% inhibitory activity at a concentration of 6.25-25 μg/mL, against Mycobacterium tuberculosis. Fluorescence properties of all the synthesized compounds have been studied. ...[more]

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