Dataset Information

Resveratrol Induces Glioma Cell Apoptosis through Activation of Tristetraprolin.

ABSTRACT: Tristetraprolin (TTP) is an AU-rich elements (AREs)-binding protein, which regulates the decay of AREs-containing mRNAs such as proto-oncogenes, anti-apoptotic genes and immune regulatory genes. Despite the low expression of TTP in various human cancers, the mechanism involving suppressed expression of TTP is not fully understood. Here, we demonstrate that Resveratrol (3,5,4'-trihydroxystilbene, Res), a naturally occurring compound, induces glioma cell apoptosis through activation of tristetraprolin (TTP). Res increased TTP expression in U87MG human glioma cells. Res-induced TTP destabilized the urokinase plasminogen activator and urokinase plasminogen activator receptor mRNAs by binding to the ARE regions containing the 3' untranslated regions of their mRNAs. Furthermore, TTP induced by Res suppressed cell growth and induced apoptosis in the human glioma cells. Because of its regulation of TTP expression, these findings suggest that the bioactive dietary compound Res can be used as a novel anti-cancer agent for the treatment of human malignant gliomas.

SUBMITTER: Ryu J

PROVIDER: S-EPMC4673414 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature

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Resveratrol Induces Glioma Cell Apoptosis through Activation of Tristetraprolin.

Ryu Jinhyun J Yoon Nal Ae NA Seong Hyemin H Jeong Joo Yeon JY Kang Seokmin S Park Nammi N Choi Jungil J Lee Dong Hoon DH Roh Gu Seob GS Kim Hyun Joon HJ Cho Gyeong Jae GJ Choi Wan Sung WS Park Jae-Yong JY Park Jeong Woo JW Kang Sang Soo SS

Molecules and cells 20151104 11

Tristetraprolin (TTP) is an AU-rich elements (AREs)-binding protein, which regulates the decay of AREs-containing mRNAs such as proto-oncogenes, anti-apoptotic genes and immune regulatory genes. Despite the low expression of TTP in various human cancers, the mechanism involving suppressed expression of TTP is not fully understood. Here, we demonstrate that Resveratrol (3,5,4'-trihydroxystilbene, Res), a naturally occurring compound, induces glioma cell apoptosis through activation of tristetrapr ...[more]

PMID: 26537190

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Dataset Information

Resveratrol Induces Glioma Cell Apoptosis through Activation of Tristetraprolin.

Publications

Resveratrol Induces Glioma Cell Apoptosis through Activation of Tristetraprolin.

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