Loss of synaptic Zn2+ transporter function increases risk of febrile seizures.
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ABSTRACT:
SUBMITTER: Hildebrand MS
PROVIDER: S-EPMC4673435 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Publications
Loss of synaptic Zn2+ transporter function increases risk of febrile seizures.
Hildebrand Michael S MS Phillips A Marie AM Mullen Saul A SA Adlard Paul A PA Hardies Katia K Damiano John A JA Wimmer Verena V Bellows Susannah T ST McMahon Jacinta M JM Burgess Rosemary R Hendrickx Rik R Weckhuysen Sarah S Suls Arvid A De Jonghe Peter P Scheffer Ingrid E IE Petrou Steven S Berkovic Samuel F SF Reid Christopher A CA
Scientific reports 20151209
Febrile seizures (FS) are the most common seizure syndrome and are potentially a prelude to more severe epilepsy. Although zinc (Zn(2+)) metabolism has previously been implicated in FS, whether or not variation in proteins essential for Zn(2+) homeostasis contributes to susceptibility is unknown. Synaptic Zn(2+) is co-released with glutamate and modulates neuronal excitability. SLC30A3 encodes the zinc transporter 3 (ZNT3), which is primarily responsible for moving Zn(2+) into synaptic vesicles. ...[more]
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