Ontology highlight
ABSTRACT:
SUBMITTER: Liu X
PROVIDER: S-EPMC4673493 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Liu Xiaoli X Hall Sean R R SRR Wang Zhihong Z Huang He H Ghanta Sailaja S Di Sante Moises M Leri Annarosa A Anversa Piero P Perrella Mark A MA
Nature communications 20151123
Striated preferentially expressed gene (Speg) is a member of the myosin light chain kinase family. We previously showed that disruption of the Speg gene locus in mice leads to a dilated cardiomyopathy with immature-appearing cardiomyocytes. Here we show that cardiomyopathy of Speg(-/-) mice arises as a consequence of defects in cardiac progenitor cell (CPC) function, and that neonatal cardiac dysfunction can be rescued by in utero injections of wild-type CPCs into Speg(-/-) foetal hearts. CPCs h ...[more]