Ontology highlight
ABSTRACT:
SUBMITTER: Paramo T
PROVIDER: S-EPMC4673606 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Paramo Teresa T Tomasio Susana M SM Irvine Kate L KL Bryant Clare E CE Bond Peter J PJ
Scientific reports 20151209
Bacterial outer membrane lipopolysaccharide (LPS) potently stimulates the mammalian innate immune system, and can lead to sepsis, the primary cause of death from infections. LPS is sensed by Toll-like receptor 4 (TLR4) in complex with its lipid-binding coreceptor MD-2, but subtle structural variations in LPS can profoundly modulate the response. To better understand the mechanism of LPS-induced stimulation and bacterial evasion, we have calculated the binding affinity to MD-2 of agonistic and an ...[more]