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Treating hepatitis C - what's new?

ABSTRACT: Chronic hepatitis C infection causes cirrhosis, liver failure and hepatocellular carcinoma, and is the most common indication for liver transplantation. Hepatitis C is curable and complications can be prevented. Until recently, treatment regimens involved peginterferon alfa. Although effective, their widespread use is limited by treatment-related toxicity. A number of direct-acting drugs for hepatitis C, such as sofosbuvir, have recently been developed and target multiple steps in the viral life cycle. These drugs are used in combination in interferon-free regimens. Short courses are highly effective with minimal toxicity.

SUBMITTER: Thompson AJ

PROVIDER: S-EPMC4674032 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Treating hepatitis C - what's new?

Thompson Alex J AJ Holmes Jacinta A JA

Australian Prescriber 20150918 6

Chronic hepatitis C infection causes cirrhosis, liver failure and hepatocellular carcinoma, and is the most common indication for liver transplantation. Hepatitis C is curable and complications can be prevented. Until recently, treatment regimens involved peginterferon alfa. Although effective, their widespread use is limited by treatment-related toxicity. A number of direct-acting drugs for hepatitis C, such as sofosbuvir, have recently been developed and target multiple steps in the viral life ...[more]

PMID: 26843711

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