Unknown

Dataset Information

0

Retinal Arteriolar Morphometry Based on Full Width at Half Maximum Analysis of Spectral-Domain Optical Coherence Tomography Images.


ABSTRACT: OBJECTIVES:In this study, we develop a microdensitometry method using full width at half maximum (FWHM) analysis of the retinal vascular structure in a spectral-domain optical coherence tomography (SD-OCT) image and present the application of this method in the morphometry of arteriolar changes during hypertension. METHODS:Two raters using manual and FWHM methods measured retinal vessel outer and lumen diameters in SD-OCT images. Inter-rater reproducibility was measured using coefficients of variation (CV), intraclass correlation coefficient and a Bland-Altman plot. OCT images from forty-three eyes of 43 hypertensive patients and 40 eyes of 40 controls were analyzed using an FWHM approach; wall thickness, wall cross-sectional area (WCSA) and wall to lumen ratio (WLR) were subsequently calculated. RESULTS:Mean difference in inter-rater agreement ranged from -2.713 to 2.658 ?m when using a manual method, and ranged from -0.008 to 0.131 ?m when using a FWHM approach. The inter-rater CVs were significantly less for the FWHM approach versus the manual method (P < 0.05). Compared with controls, the wall thickness, WCSA and WLR of retinal arterioles were increased in the hypertensive patients, particular in diabetic hypertensive patients. CONCLUSIONS:The microdensitometry method using a FWHM algorithm markedly improved inter-rater reproducibility of arteriolar morphometric analysis, and SD-OCT may represent a promising noninvasive method for in vivo arteriolar morphometry.

SUBMITTER: Tong YH 

PROVIDER: S-EPMC4674079 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

altmetric image

Publications

Retinal Arteriolar Morphometry Based on Full Width at Half Maximum Analysis of Spectral-Domain Optical Coherence Tomography Images.

Tong Yu Hua YH   Zhu Tie Pei TP   Zhao Ze Lin ZL   Zhan Hai Jing HJ   Jiang Fang Zheng FZ   Lian Heng Li HL  

PloS one 20151209 12


<h4>Objectives</h4>In this study, we develop a microdensitometry method using full width at half maximum (FWHM) analysis of the retinal vascular structure in a spectral-domain optical coherence tomography (SD-OCT) image and present the application of this method in the morphometry of arteriolar changes during hypertension.<h4>Methods</h4>Two raters using manual and FWHM methods measured retinal vessel outer and lumen diameters in SD-OCT images. Inter-rater reproducibility was measured using coef  ...[more]

Similar Datasets

| S-EPMC3015152 | biostudies-literature
| S-EPMC3342198 | biostudies-other
| S-EPMC7804964 | biostudies-literature
| S-EPMC3496561 | biostudies-literature
| S-EPMC4555843 | biostudies-literature
| S-EPMC3993014 | biostudies-literature
| S-EPMC7813855 | biostudies-literature
| S-EPMC6258318 | biostudies-literature
| S-EPMC6704163 | biostudies-literature
| S-EPMC4114772 | biostudies-literature