Ontology highlight
ABSTRACT:
SUBMITTER: Kumar V
PROVIDER: S-EPMC4674273 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Kumar Vinod V Bouameur Jamal-Eddine JE Bär Janina J Rice Robert H RH Hornig-Do Hue-Tran HT Roop Dennis R DR Schwarz Nicole N Brodesser Susanne S Thiering Sören S Leube Rudolf E RE Wiesner Rudolf J RJ Vijayaraj Preethi P Brazel Christina B CB Heller Sandra S Binder Hans H Löffler-Wirth Henry H Seibel Peter P Magin Thomas M TM
The Journal of cell biology 20151201 5
Keratin intermediate filaments (KIFs) protect the epidermis against mechanical force, support strong adhesion, help barrier formation, and regulate growth. The mechanisms by which type I and II keratins contribute to these functions remain incompletely understood. Here, we report that mice lacking all type I or type II keratins display severe barrier defects and fragile skin, leading to perinatal mortality with full penetrance. Comparative proteomics of cornified envelopes (CEs) from prenatal Kt ...[more]