Unknown

Dataset Information

0

T cells compete by cleaving cell surface CD27 and blocking access to CD70-bearing APCs.


ABSTRACT: T cells compete against each other for access to molecules on APCs in addition to peptide/MHC complexes. However, the identity of cell surface molecules that influence T-cell competition, other than peptide/MHC, have yet to be defined. Here, we identify CD70, a TNF ligand expressed on activated APCs, as an important mediator of T-cell competition for APCs. Upon engagement of CD27 by CD70, CD27 is proteolytically cleaved from the surface of the interacting CD8(+) T cell and captured by CD70 expressing dendritic cells. The capture of CD27 effectively masks CD70 on APCs, disallowing the interaction with CD27 on other competing T cells. Collectively, our data indicate that T cells compete against each other for access to the TNF-ligand CD70, an interaction that affects the duration and potency of T cell/DC interactions, thus influencing the repertoire of responding CD8(+) T cells to self or foreign antigens.

SUBMITTER: Burchill MA 

PROVIDER: S-EPMC4674305 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature

altmetric image

Publications

T cells compete by cleaving cell surface CD27 and blocking access to CD70-bearing APCs.

Burchill Matthew A MA   Tamburini Beth A BA   Kedl Ross M RM  

European journal of immunology 20150803 11


T cells compete against each other for access to molecules on APCs in addition to peptide/MHC complexes. However, the identity of cell surface molecules that influence T-cell competition, other than peptide/MHC, have yet to be defined. Here, we identify CD70, a TNF ligand expressed on activated APCs, as an important mediator of T-cell competition for APCs. Upon engagement of CD27 by CD70, CD27 is proteolytically cleaved from the surface of the interacting CD8(+) T cell and captured by CD70 expre  ...[more]

Similar Datasets

| S-EPMC4232384 | biostudies-literature
2020-07-10 | GSE129251 | GEO
| S-EPMC3750068 | biostudies-literature
| S-EPMC11007004 | biostudies-literature
| S-EPMC10079957 | biostudies-literature
| S-EPMC3706991 | biostudies-literature
| S-EPMC4635726 | biostudies-other
| S-EPMC8734249 | biostudies-literature
| S-EPMC8484739 | biostudies-literature
| S-EPMC10041113 | biostudies-literature